Cell functionalization with recently developed various nano‐ and microcarriers for therapeutics has significantly expanded the application of cell therapy and targeted drug delivery for the effective treatment of a number of diseases. The aim of this progress report is to review the most recent advances in cell‐based drug vehicles designed as biological transporter platforms for the targeted delivery of different drugs. For the design of cell‐based drug vehicles, different pathways of cell functionalization, such as covalent and noncovalent surface modifications, internalization of carriers are considered in greater detail together with approaches for cell visualization in vivo. In addition, several animal models for the study of cell‐assisted drug delivery are discussed. Finally, possible future developments and applications of cell‐assisted drug vehicles toward targeted transport of drugs to a designated location with no or minimal immune response and toxicity are addressed in light of new pathways in the field of nanomedicine.

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基于细胞的药物递送以及纳米和微载体在细胞功能化中的应用

具有最近开发的各种纳米和微载体用于治疗的细胞功能化已大大扩展了细胞治疗和靶向药物递送的应用范围，以有效治疗多种疾病。这份进展报告的目的是回顾基于细胞的药物载体的最新进展，这些药物被设计为针对不同药物的靶向转运的生物转运平台。对于基于细胞的药物媒介物的设计，需要对细胞功能化的不同途径（例如共价和非共价表面修饰），载体的内在化以及体内细胞可视化方法进行更详细的考虑。此外，还讨论了几种用于研究细胞辅助药物递送的动物模型。最后，