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Adipose Composition and Heart Failure Prognosis
Journal of the American College of Cardiology ( IF 24.0 ) Pub Date : 2017-12-01 , DOI: 10.1016/j.jacc.2017.10.017
Carl J. Lavie , Richard V. Milani , Hector O. Ventura

SEE PAGE 2739 O verweight and obesity have substantial adverse effects on the cardiovascular system, leading to increases in many of the major cardiovascular disease (CVD) risk factors, including dyslipidemia, hypertension/left ventricular hypertrophy, glucose abnormalities (metabolic syndrome and diabetes mellitus), inflammation, and physical inactivity (2–4). Not surprisingly, almost all CVD is increased in the setting of obesity, including hypertension, coronary heart disease, atrial fibrillation, and heart failure (HF) (2–4). Considering that hypertension, left ventricular hypertrophy, and coronary heart disease are all major contributors to HF, and that obesity has direct and indirect effects to increase systolic and, particularly, diastolic ventricular dysfunction, it is not surprising that HF is especially increased in the setting of obesity (4). Despite the increased risk of developing CVD, especially HF, from obesity, many studies and metaanalyses have demonstrated a strong obesity paradox, meaning that heavier patients with CVD (including HF) often have a better prognosis than do thinner patients (2–5). This obesity paradox has been demonstrated in patients with HF with both reduced left ventricular ejection fraction (HFrEF),

中文翻译:

脂肪成分和心力衰竭预后

参见第 2739 页 超重和肥胖对心血管系统有重大不利影响,导致许多主要心血管疾病 (CVD) 风险因素增加,包括血脂异常、高血压/左心室肥大、葡萄糖异常(代谢综合征和糖尿病) 、炎症和缺乏身体活动 (2-4)。毫不奇怪,几乎所有 CVD 在肥胖的情况下都会增加,包括高血压、冠心病、心房颤动和心力衰竭 (HF) (2-4)。考虑到高血压、左心室肥厚和冠心病都是导致 HF 的主要因素,而且肥胖会直接和间接地增加收缩期,尤其是舒张期心室功能障碍,HF 在肥胖的情况下特别增加并不奇怪 (4)。尽管肥胖会增加 CVD,尤其是 HF 的风险,但许多研究和荟萃分析已经证明了强烈的肥胖悖论,这意味着患有 CVD 的较重的患者(包括 HF)通常比较瘦的患者具有更好的预后 (2-5)。这种肥胖悖论已在左心室射血分数 (HFrEF) 降低的 HF 患者中得到证实,
更新日期:2017-12-01
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