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The Role of Nanomechanics in Healthcare
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2017-11-29 , DOI: 10.1002/adhm.201700793
Pranjal Nautiyal 1 , Fahad Alam 2 , Kantesh Balani 2 , Arvind Agarwal 1
Affiliation  

Nanomechanics has played a vital role in pushing our capability to detect, probe, and manipulate the biological species, such as proteins, cells, and tissues, paving way to a deeper knowledge and superior strategies for healthcare. Nanomechanical characterization techniques, such as atomic force microscopy, nanoindentation, nanotribology, optical tweezers, and other hybrid techniques have been utilized to understand the mechanics and kinetics of biospecies. Investigation of the mechanics of cells and tissues has provided critical information about mechanical characteristics of host body environments. This information has been utilized for developing biomimetic materials and structures for tissue engineering and artificial implants. This review summarizes nanomechanical characterization techniques and their potential applications in healthcare research. The principles and examples of label‐free detection of cancers and myocardial infarction by nanomechanical cantilevers are discussed. The vital importance of nanomechanics in regenerative medicine is highlighted from the perspective of material selection and design for developing biocompatible scaffolds. This review interconnects the advancements made in fundamental materials science research and biomedical technology, and therefore provides scientific insight that is of common interest to the researchers working in different disciplines of healthcare science and technology.

中文翻译:

纳米力学在医疗保健中的作用

纳米力学在推动我们检测,探测和操纵生物物种(如蛋白质,细胞和组织)的能力方面发挥了至关重要的作用,为深入了解和更好的医疗保健方法铺平了道路。纳米力学表征技术,例如原子力显微镜,纳米压痕,纳米摩擦学,光学镊子和其他混合技术已被用于了解生物物种的力学和动力学。对细胞和组织力学的研究提供了有关宿主环境机械特性的重要信息。该信息已被用于开发仿生材料和组织工程和人造植入物的结构。这篇综述总结了纳米力学表征技术及其在医疗保健研究中的潜在应用。讨论了通过纳米机械悬臂对癌症和心肌梗死进行无标记检测的原理和实例。从用于开发生物相容性支架的材料选择和设计的角度强调了纳米力学在再生医学中的至关重要性。这篇综述将基础材料科学研究和生物医学技术的进步联系在一起,因此提供了对医疗科学和技术不同学科的研究人员普遍感兴趣的科学见解。从用于开发生物相容性支架的材料选择和设计的角度强调了纳米力学在再生医学中的至关重要性。这篇综述将基础材料科学研究和生物医学技术的进步联系在一起,因此提供了对医疗科学和技术不同学科的研究人员普遍感兴趣的科学见解。从用于开发生物相容性支架的材料选择和设计的角度强调了纳米力学在再生医学中的至关重要性。这篇综述将基础材料科学研究和生物医学技术的进步联系在一起,因此提供了对医疗科学和技术不同学科的研究人员普遍感兴趣的科学见解。
更新日期:2017-11-29
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