Desferrioxamine B (DFOB) was discovered in the late 1950s as a hydroxamic acid metabolite of the soil bacterium Streptomyces pilosus. The exquisite affinity of DFOB for Fe(III) identified its potential for removing excess iron from patients with transfusion-dependent hemoglobin disorders. Many studies have used semisynthetic chemistry to produce DFOB adducts with new properties and broad-ranging functions. More recent approaches in chemical biology have revealed some nuances of DFOB biosynthesis and discovered new DFOB-derived drugs and radiometal imaging agents. The current and potential applications of DFOB continue to inspire a rich body of chemical biology research focused on this bacterial metabolite.

中文翻译：

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去铁胺B的化学生物学研究进展

去铁胺B（DFOB）在1950年代后期被发现为土壤细菌毛状链霉菌的异羟肟酸代谢产物。DFOB对Fe（III）的精湛亲和力证明了它具有从输血依赖型血红蛋白疾病患者中去除过量铁的潜力。许多研究已使用半合成化学方法生产具有新特性和广泛功能的DFOB加合物。化学生物学的最新方法揭示了DFOB生物合成的一些细微差别，并发现了新的DFOB衍生药物和放射性金属显像剂。DFOB的当前和潜在应用继续激发着大量针对这种细菌代谢产物的化学生物学研究。