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Catalyst- and solvent-free bisphosphinylation of isothiocyanates: a practical method for the synthesis of bisphosphinoylaminomethanes
Green Chemistry ( IF 9.8 ) Pub Date : 2017-11-27 00:00:00 , DOI: 10.1039/c7gc03101g
Li-Rong Wen 1, 2, 3, 4, 5 , Yong-Xu Sun 1, 2, 3, 4, 5 , Jin-Wei Zhang 5, 6, 7, 8 , Wei-Si Guo 1, 2, 3, 4, 5 , Ming Li 1, 2, 3, 4, 5
Affiliation  

A general and convenient double addition of phosphine oxides to isothiocyanates is described. It is a practically useful protocol for the construction of bisphosphinoylaminomethanes. The reaction can be carried out smoothly under metal- and solvent-free conditions. It also features a broad substrate scope, simple operation and purification. A possible mechanism involving a tandem double nucleophilic addition/H2S elimination/in situ imine reduction process is proposed.

中文翻译:

异硫氰酸酯的无催化剂和无溶剂双亚膦酰基化:合成双膦酰基氨基甲烷的实用方法

描述了将氧化膦一般且方便地双重加到异硫氰酸酯中的方法。这是构建双膦酰基氨基甲烷的实用方法。该反应可以在无金属和无溶剂的条件下平稳地进行。它还具有广泛的底物范围,简单的操作和纯化。提出了可能的机制,包括串联双亲核加成/ H 2 S消除/原位亚胺还原过程。
更新日期:2018-01-02
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