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Combined Phycocyanin and Hematoporphyrin Monomethyl Ether for Breast Cancer Treatment via Photosensitizers Modified Fe3O4 Nanoparticles Inhibiting the Proliferation and Migration of MCF-7 Cells
Biomacromolecules ( IF 6.2 ) Pub Date : 2017-12-19 00:00:00 , DOI: 10.1021/acs.biomac.7b01197
Shi-Wei Du 1 , Ling-Kun Zhang 1 , Kaibin Han 1 , Shaoping Chen 1 , Zhuoyan Hu 1 , Wuya Chen 1 , Kaikai Hu 1 , Liang Yin 1 , Baoyan Wu 1 , Yan-Qing Guan 1
Affiliation  

Photodynamic therapy (PDT), combining the laser and photosensitizers to kill tumor cells, has the potential to address many current medical requirements. In this study, magnetic Fe3O4 nanoparticles were first employed as cores and modified with oleic acid (OA) and 3-triethoxysilyl-1-propanamine. Then, the photosensitizers phycocyanin (PC) and hematoporphyrin monomethyl ether (HMME), which might be able to stimulate the cell release of reactive oxygen species after the irradiation of a near-infrared (NIR) laser, were grafted on the surface of such nanoparticles. Our results revealed the high-efficiency inhibition of breast cancer MCF-7 cells growing upon near-infrared irradiation both in vitro and in vivo. Furthermore, it was the synergy between the natural photosensitizers PC and the synthetic photosensitizers HMME that deeply influenced such inhibition compared to the groups that used either of these medicines alone. To utilize the combination of different photosensitive agents, our study thus provides a new strategy for breast cancer treatment.

中文翻译:

藻蓝蛋白和血卟啉单甲醚联合用于光敏剂修饰的Fe 3 O 4纳米粒子抑制MCF-7细胞增殖和迁移的乳腺癌治疗。

结合激光和光敏剂杀死肿瘤细胞的光动力疗法(PDT)具有解决当前许多医学要求的潜力。在这项研究中,磁性Fe 3 O 4纳米粒子首先被用作核心,并用油酸(OA)和3-三乙氧基甲硅烷基-1-丙胺改性。然后,将光敏剂藻蓝蛋白(PC)和血卟啉单甲醚(HMME)移植到此类纳米颗粒的表面,它们可能在近红外(NIR)激光照射后刺激细胞释放活性氧。 。我们的研究结果表明,在体外和体内,近红外辐射对乳腺癌MCF-7细胞均具有高效抑制作用。此外,与单独使用这两种药物中的一种相比,天然光敏剂PC和合成光敏剂HMME之间的协同作用对这种抑制作用产生了深远的影响。为了利用不同的光敏剂的组合,
更新日期:2017-12-19
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