Trends in Cell Biology ( IF 19.0 ) Pub Date : 2017-11-27 , DOI: 10.1016/j.tcb.2017.10.006 Luana Schito , Sergio Rey
Molecular oxygen (O2) is a universal electron acceptor that enables ATP synthesis through mitochondrial respiration in all metazoans. Consequently, hypoxia (low O2) has arisen as an organizing principle for cellular evolution, metabolism, and (patho)biology, eliciting a remarkable panoply of metabolic adaptations that trigger transcriptional, translational, post-translational, and epigenetic responses to determine cellular fitness. In this review we summarize current and emerging cell-autonomous molecular mechanisms that induce hypoxic metabolic reprogramming in health and disease.
中文翻译:
低氧中的细胞自主代谢重编程
分子氧(O 2)是一种通用电子受体,可通过所有后生动物中的线粒体呼吸作用来实现ATP合成。因此,缺氧(低O 2)已作为细胞进化,代谢和(病理)生物学的组织原理而出现,引发了一系列新奇的代谢适应,这些代谢适应触发了转录,翻译,翻译后和表观遗传反应来确定细胞的适应性。 。在这篇综述中,我们总结了诱导健康和疾病中缺氧代谢重编程的当前和新兴的细胞自主分子机制。