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cGAS drives noncanonical-inflammasome activation in age-related macular degeneration
Nature Medicine ( IF 82.9 ) Pub Date : 2017-11-27 , DOI: 10.1038/nm.4450 Nagaraj Kerur , Shinichi Fukuda , Daipayan Banerjee , Younghee Kim , Dongxu Fu , Ivana Apicella , Akhil Varshney , Reo Yasuma , Benjamin J Fowler , Elmira Baghdasaryan , Kenneth M Marion , Xiwen Huang , Tetsuhiro Yasuma , Yoshio Hirano , Vlad Serbulea , Meenakshi Ambati , Vidya L Ambati , Yuji Kajiwara , Kameshwari Ambati , Shuichiro Hirahara , Ana Bastos-Carvalho , Yuichiro Ogura , Hiroko Terasaki , Tetsuro Oshika , Kyung Bo Kim , David R Hinton , Norbert Leitinger , John C Cambier , Joseph D Buxbaum , M Cristina Kenney , S Michal Jazwinski , Hiroshi Nagai , Isao Hara , A Phillip West , Katherine A Fitzgerald , SriniVas R Sadda , Bradley D Gelfand , Jayakrishna Ambati
Nature Medicine ( IF 82.9 ) Pub Date : 2017-11-27 , DOI: 10.1038/nm.4450 Nagaraj Kerur , Shinichi Fukuda , Daipayan Banerjee , Younghee Kim , Dongxu Fu , Ivana Apicella , Akhil Varshney , Reo Yasuma , Benjamin J Fowler , Elmira Baghdasaryan , Kenneth M Marion , Xiwen Huang , Tetsuhiro Yasuma , Yoshio Hirano , Vlad Serbulea , Meenakshi Ambati , Vidya L Ambati , Yuji Kajiwara , Kameshwari Ambati , Shuichiro Hirahara , Ana Bastos-Carvalho , Yuichiro Ogura , Hiroko Terasaki , Tetsuro Oshika , Kyung Bo Kim , David R Hinton , Norbert Leitinger , John C Cambier , Joseph D Buxbaum , M Cristina Kenney , S Michal Jazwinski , Hiroshi Nagai , Isao Hara , A Phillip West , Katherine A Fitzgerald , SriniVas R Sadda , Bradley D Gelfand , Jayakrishna Ambati
cGAS drives noncanonical-inflammasome activation in age-related macular degeneration
中文翻译：
cGAS在与年龄有关的黄斑变性中驱动非规范性炎症小体活化
cGAS在与年龄有关的黄斑变性中驱动非规范性炎症小体活化
更新日期：2017-11-28
cGAS drives noncanonical-inflammasome activation in age-related macular degeneration, Published online: 27 November 2017; doi:10.1038/nm.4450
Degeneration of the retinal pigment epithelium is a hallmark of geographic atrophy, a type of age-related macular degeneration. Kerur et al. show that this degeneration results from a multistep pathway in which mitochondrial dysfunction in RPE cells, triggered by accumulation of Alu RNA, leads to activation of the noncanonical inflammasome via a cGAS–STING–IRF3 signaling axis.中文翻译：
cGAS在与年龄有关的黄斑变性中驱动非规范性炎症小体活化
cGAS在与年龄有关的黄斑变性中驱动非规范性炎症小体活化
cGAS在与年龄有关的黄斑变性中驱动非规范性炎症小体激活，在线发布：2017年11月27日；doi：10.1038 / nm.4450
视网膜色素上皮的变性是地理萎缩的标志，这是一种与年龄有关的黄斑变性。Kerur等。结果表明，这种变性是由多步途径引起的，其中Rlu细胞中的线粒体功能障碍由Alu RNA的积累触发，通过cGAS–STING–IRF3信号转导轴导致非规范性炎症小体的活化。
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