当前位置: X-MOL 学术Nat. Chem. Biol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
5-Formylcytosine to cytosine conversion by C–C bond cleavage in vivo
Nature Chemical Biology ( IF 14.8 ) Pub Date : 2017-11-27 , DOI: 10.1038/nchembio.2531
Katharina Iwan , René Rahimoff , Angie Kirchner , Fabio Spada , Arne S Schröder , Olesea Kosmatchev , Shqiponja Ferizaj , Jessica Steinbacher , Edris Parsa , Markus Müller , Thomas Carell

5-Formylcytosine to cytosine conversion by C–C bond cleavage in vivo

5-Formylcytosine to cytosine conversion by C–C bond cleavage <i>in vivo</i>, Published online: 27 November 2017; doi:10.1038/nchembio.2531

Direct conversion of 5-fdC into dC by C–C bond breakage is revealed by metabolic tracing studies through incorporation of synthetic stable isotope- and (R)-2′-fluorine-labeled dC and fdC derivatives into the genome of cultured mammalian cells.


中文翻译:

通过体内C–C键裂解将5-甲酰基胞嘧啶转化为胞嘧啶

通过体内C–C键裂解将5-甲酰基胞嘧啶转化为胞嘧啶

通过体内C–C键裂解将5-甲酰基胞嘧啶转化为胞嘧啶</ i>,在线发布:2017年11月27日;doi:10.1038 / nchembio.2531

通过代谢追踪研究,通过将合成的稳定同位素和(R)-2'-氟标记的dC和fdC衍生物掺入培养的哺乳动物细胞的基因组中,通过代谢示踪研究揭示了通过c–C键断裂将5-fdC直接转化为dC的现象。
更新日期:2017-11-28
down
wechat
bug