当前位置: X-MOL 学术Nat. Chem. Biol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Inhibition of Delta-induced Notch signaling using fucose analogs
Nature Chemical Biology ( IF 14.8 ) Pub Date : 2017-11-27 , DOI: 10.1038/nchembio.2520
Michael Schneider , Vivek Kumar , Lars Ulrik Nordstrøm , Lei Feng , Hideyuki Takeuchi , Huilin Hao , Vincent C Luca , K Christopher Garcia , Pamela Stanley , Peng Wu , Robert S Haltiwanger

Inhibition of Delta-induced Notch signaling using fucose analogs

Inhibition of Delta-induced Notch signaling using fucose analogs, Published online: 27 November 2017; doi:10.1038/nchembio.2520

Protein O-fucosyltransferase 1 (Pofut1) regulates Notch activity by adding O-fucose residues to its extracellular domain. Fucose analogs were identified that inhibited Delta-mediated Notch binding and activation but spared Jagged1-mediated signaling.


中文翻译:

使用岩藻糖类似物抑制Delta诱导的Notch信号传导

使用岩藻糖类似物抑制Delta诱导的Notch信号传导

使用岩藻糖类似物抑制Delta诱导的Notch信号传导,在线发布:2017年11月27日; doi:10.1038 / nchembio.2520

蛋白质O-岩藻糖基转移酶1(Pofut1)通过向其胞外域添加O-岩藻糖残基来调节Notch活性。确定了岩藻糖类似物可以抑制Delta介导的Notch结合和激活,但保留了Jagged1介导的信号转导。
更新日期:2017-11-28
down
wechat
bug