For effective drug design and development, an integrated process utilizing all available information from structural, thermodynamic, and biological studies plays a very important role. To understand the energy basis of molecular interactions utilizing various thermodynamic methods, volumetric and acoustic studies are vital early in the development process of any drug toward an optimal energy interaction profile while retaining a good pharmacological assay. In this article, we are reporting the data of densities (ρ) and speeds of sound (u) of an antiarrhythmic agent, namely, procainamide hydrochloride in an aqueous binary and aqueous solution of amino acids, i.e., l-alanine and l-valine at T = (298.15, 308.15 and 318.15) K. Different thermodynamic parameters such as the apparent molar volume (V_ϕ) of the solute, the isentropic compressibility (κ_s) of the solution, and the apparent molar isentropic compressibility (κ_ϕ) of procainamide hydrochloride in water and aqueous solutions of l-alanine and l-valine have been computed using the density and speed of sound data at different temperatures. The limiting apparent molar volume (V_ϕ⁰) of solute and the limiting apparent molar compressibility (κ_ϕ⁰) of solute in binary and ternary aqueous solutions have been obtained by extrapolating the plots. The results have been interpreted in light of the competing solute–solute and solute–solvent interactions.

中文翻译：

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盐酸普鲁卡因酰胺在不同温度下的二元和（水+氨基酸）三元水溶液中的体积和声学性质的研究

对于有效的药物设计和开发，利用来自结构，热力学和生物学研究的所有可用信息的集成过程起着非常重要的作用。为了了解利用各种热力学方法进行分子相互作用的能量基础，在任何药物的开发过程中，朝着最佳能量相互作用模式发展并保持良好药理学检测的过程中，体积和声学研究至关重要。在本文中，我们报告了抗心律不齐药物（即普鲁卡因酰胺盐酸盐）在氨基酸（即l-丙氨酸和l-缬氨酸）的二元水溶液和水溶液中的密度（ρ）和声速（u）的数据。在T=（298.15，308.15和318.15）K.不同的热力学参数，如表观摩尔体积（V _φ溶质），等熵压缩（κ_小号的溶液），和表观摩尔等熵压缩（κ _φ普鲁卡因胺的）使用不同温度下的声音数据的密度和速度，可以计算出水和l-丙氨酸和l-缬氨酸水溶液中的盐酸盐。限制表观摩尔体积（V _φ ⁰）溶质的和限制性的表观摩尔可压缩性（κ _φ ⁰通过外推得到二元和三元水溶液中的溶质）。根据竞争的溶质-溶质和溶质-溶剂相互作用对结果进行了解释。