Cardiovascular disease is presently the number one cause of death worldwide. Current stents used to treat cardiovascular disease have a litany of unacceptable shortcomings: adverse clinical events include restenosis, neointimal hyperplasia, thrombosis, inflammation, and poor re-endothelialization. We have developed a biocompatible, multifunctional, peptide amphiphile-based nanomatrix coating for stents. In this study, we evaluated the ability of the nanomatrix coated stent to simultaneously address the issues facing current stents under physiological flow conditions in vitro. We found that the nanomatrix coated stent could increase endothelial cell migration, adhesion, and proliferation (potential for re-endothelialization), discourage smooth muscle cell migration and adhesion (potential to reduce neointimal hyperplasia and restenosis), and decrease both platelet activation and adhesion (potential to prevent thrombosis) as well as monocyte adhesion (potential to attenuate inflammatory responses) under physiological flow conditions in vitro. These promising results demonstrate the potential clinical utility of this nanomatrix stent coating, and highlight the importance of biocompatibility, multifunctionality, and bioactivity in cardiovascular device design.

中文翻译：

---

纳米基质涂层支架在生理条件下可增强内皮化作用，但可减少血小板，平滑肌细胞和单核细胞的粘附

目前，心血管疾病是全球范围内第一大死亡原因。当前用于治疗心血管疾病的支架具有一系列令人无法接受的缺点：不良的临床事件包括再狭窄，新内膜增生，血栓形成，炎症和再内皮化不良。我们已经开发出了一种生物相容的，多功能，基于肽两亲物的支架纳米基质涂层。在这项研究中，我们评估了纳米基质涂层支架在体外生理流动条件下同时解决当前支架面临的问题的能力。我们发现纳米基质涂层支架可以增加内皮细胞的迁移，粘附和增殖（重新内皮化的潜力），阻止平滑肌细胞的迁移和粘附（减少新内膜增生和再狭窄的潜力），并在体外生理流动条件下降低血小板活化和粘附（可能防止血栓形成）以及单核细胞粘附（可能减弱炎症反应）。这些有希望的结果证明了这种纳米基质支架涂层的潜在临床实用性，并突出了生物相容性，多功能性和生物活性在心血管器械设计中的重要性。