当前位置: X-MOL 学术ACS Biomater. Sci. Eng. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
pH-Sensitive Zwitterionic Polymer as an Antimicrobial Agent with Effective Bacterial Targeting
ACS Biomaterials Science & Engineering ( IF 5.8 ) Pub Date : 2017-12-07 00:00:00 , DOI: 10.1021/acsbiomaterials.7b00723
Peng Liu 1 , Gang Xu 1 , Dicky Pranantyo 1 , Li Qun Xu 1 , Koon-Gee Neoh 1 , En-Tang Kang 1
Affiliation  

It is highly desirable to develop new and more potent biocompatible antimicrobial agents to reduce the increasing risk of bacterial infection worldwide. To address this problem, we prepared a smart pH-sensitive polymer, poly(N′-citraconyl-2-(3-aminopropyl-N,N-dimethylammonium)ethyl methacrylate), or P(CitAPDMAEMA), which can undergo change in functionality from a biocompatible zwitterionic polymer to an antimicrobial cationic polymer at acidic bacterial infection sites. The precursor polymer, poly(2-(3-aminopropyl-N,N-dimethylammonium)ethyl methacrylate) (P(APDMAEMA)), was first prepared by reversible addition–fragmentation chain transfer (RAFT) polymerization, and then modified with citraconic anhydride to obtain the zwitterionic P(CitAPDMAEMA). P(CitAPDMAEMA) is zwitterionic at physiological pH and exhibits low hemotoxicity and good biocompatibility. However, P(CitAPDMAEMA) can change from neutral to cationic with decreasing pH because of the hydrolysis of citraconic amide under low pH conditions. This switch leads to pronounced bacteria binding of cationic P(CitAPDMAEMA) under acidic conditions of the infection sites and significantly inhibits the growth of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). These results indicate that P(CitAPDMAEMA) is potentially a new on-demand antimicrobial agent.

中文翻译:

pH敏感的两性离子聚合物作为具有有效细菌靶向作用的抗菌剂

迫切需要开发新的和更有效的生物相容性抗菌剂,以减少全球范围内细菌感染风险的增加。为了解决这个问题,我们制备了一种智能的pH敏感聚合物,聚(N'-香豆基-2-(3-氨基丙基-NN-二甲基铵)甲基丙烯酸乙酯)或P(CitAPDMAEMA),它们的功能会发生变化从生物相容性两性离子聚合物到酸性细菌感染部位的抗菌阳离子聚合物。前体聚合物,聚(2-(3-氨基丙基-NN首先通过可逆加成-断裂链转移(RAFT)聚合反应制备甲基丙烯酸-二甲基铵)(P(APDMAEMA)),然后用柠康酸酐改性以获得两性离子P(CitAPDMAEMA)。P(CitAPDMAEMA)在生理pH下为两性离子,具有较低的血液毒性和良好的生物相容性。但是,由于柠康酰胺在低pH条件下水解,P(CitAPDMAEMA)可以随着pH值的降低而从中性变为阳离子。这种转换导致在感染部位的酸性条件下细菌明显结合阳离子P(CitAPDMAEMA),并显着抑制大肠杆菌E. coli)和金黄色葡萄球菌S. aureus)的生长)。这些结果表明,P(CitAPDMAEMA)可能是一种新的按需抗菌剂。
更新日期:2017-12-07
down
wechat
bug