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Exploring PTDH–P450BM3 Variants for the Synthesis of Drug Metabolites
ChemBioChem ( IF 3.2 ) Pub Date : 2018-01-17 , DOI: 10.1002/cbic.201700470
Nina Beyer 1 , Justyna K. Kulig 2, 3 , Marco W. Fraaije 1 , Martin A. Hayes 2 , Dick B. Janssen 1
Affiliation  

Putting up P450 by phosphite: The bifunctional fusion enzyme phosphite dehydrogenase–P450BM3 is a good system not only for the conversion of model compounds but also for the discovery of novel activities related to metabolism of human drugs, offering a potentially cost‐effective system for use in high‐throughput and large‐scale applications.
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中文翻译:

探索用于药物代谢产物合成的PTDH–P450BM3变体

用亚磷酸酯吸收P450:双功能融合酶亚磷酸酯脱氢酶– P450BM3是一个很好的系统,不仅可以转换模型化合物,而且还可以发现与人类药物代谢有关的新活性,提供了一种潜在的具有成本效益的系统在高通量和大规模应用中。
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更新日期:2018-01-17
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