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Chemical amplification accelerates reactive oxygen species triggered polymeric degradation†
Biomaterials Science ( IF 6.6 ) Pub Date : 2017-11-28 00:00:00 , DOI: 10.1039/c7bm00758b
Sangeun Lee 1, 2, 3, 4, 5 , Alexandra Stubelius 1, 2, 3, 4, 6 , Jason Olejniczak 1, 2, 3, 4 , Hongje Jang 7, 8, 9, 10 , Viet Anh Nguyen Huu 1, 2, 3, 4 , Adah Almutairi 1, 2, 3, 4, 5
Affiliation  

Chemical amplification is a known strategy for improving the sensitivity of stimuli-responsive polymers. However, the chemical amplification effect has never been fully examined. Many questions remain about its mechanism and efficacy, obstructing its further implementation. Here, we design and demonstrate a reactive oxygen species (ROS) responsive polymer (ROS-ARP) with a chemical amplification strategy to dismiss these concerns. The ROS-ARP is designed to change the hydrophilicity by ROS, revealing a carboxylic acid, which also catalyzes ketal hydrolysis along the polymer backbone. The chemical amplification strategy of ROS-ARP accelerated the polymer degradation up to 17 fold compared to a previously reported ROS-responsive polymer. To investigate the mechanism behind this increased acceleration, we compared the degradation kinetics in various environments. Additionally, other effects such as hydrophilicity changes were excluded. The accelerated degradation of ROS-ARP is evaluated as a potential drug delivery system, demonstrating on-demand cargo release from the formulated polymeric particles.

中文翻译:

化学放大作用加速了活性氧的触发,引发了聚合物的降解

化学扩增是用于改善刺激响应性聚合物的敏感性的已知策略。但是,化学放大作用尚未得到充分研究。关于其机制和功效,仍然存在许多疑问,阻碍了其进一步实施。在这里,我们设计并演示了具有化学放大策略的活性氧(ROS)响应型聚合物(ROS-ARP),以消除这些顾虑。ROS-ARP旨在通过ROS改变亲水性,从而揭示出一种羧酸,该羧酸还催化沿聚合物主链的缩酮水解。与先前报道的ROS响应聚合物相比,ROS-ARP的化学扩增策略将聚合物降解加速了17倍。为了研究这种加速现象背后的机制,我们比较了各种环境下的降解动力学。另外,排除了诸如亲水性改变的其他影响。ROS-ARP的加速降解被评估为潜在的药物递送系统,证明了从配制的聚合物颗粒中按需释放货物。
更新日期:2017-11-28
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