With increasing concerns for the environmental impact of chemical manufacturing, reagents and processes that align with the principles of green chemistry are essential. The fundamental oxidation of organic substrates is no exception and in this report three distinct modes of green oxidation are demonstrated in a vortex fluidic device (VFD) under continuous flow: aerobic oxidation, oxidation using chlorine bleach, and oxidation using hydrogen peroxide. The VFD, which is a thin film microfluidic platform, revealed clear advantages in these oxidations in comparison to traditional batch reactor processing: Efficient mass transfer of gases in the dynamic thin film increased the rate of aerobic oxidations, and the intense micromixing allowed multi-phase oxidations to proceed efficiently, obviating the need for organic solvents and phase transfer catalysts. In addition, the rapid dissipation of heat in the VFD also improved the safety profile and stereoselectivity for exothermic oxidations.

中文翻译：

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在连续流动下，由涡流驱动的薄膜中促进了有机氧化

随着对化学生产对环境影响的关注日益增加，符合绿色化学原理的试剂和工艺至关重要。有机基质的基本氧化也不例外，在本报告中，在连续流动的涡流装置（VFD）中证明了三种不同的绿色氧化方式：好氧氧化，使用氯漂白剂的氧化和使用过氧化氢的氧化。与传统的间歇式反应器工艺相比，VFD是薄膜微流体平台，在这些氧化反应中显示出明显的优势：动态薄膜中气体的有效传质提高了好氧氧化的速率，并且剧烈的微混合使多相反应成为可能。氧化有效地进行，消除了对有机溶剂和相转移催化剂的需求。此外，VFD中热量的快速散发还改善了放热氧化的安全性和立体选择性。