We report an efficient synthetic method for CF₃-containing oxazolines via trifluoromethylation of allylamides by using Togni reagent in the presence of alkali metal iodides, which play a key role in selective production of the desired oxazoline. The reaction did not proceed efficiently with copper catalysts commonly used for oxytrifluoromethylations. Our method afforded a wide variety of CF₃-containing oxazolines, which are potential candidates for pharmaceuticals, agrochemicals, and functional materials.

中文翻译：

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在碱金属碘化物存在下，用Togni试剂通过烯丙基酰胺的三氟甲基化合成含CF ₃的恶唑啉

我们报告了一种有效的合成方法，通过在碱金属碘化物的存在下使用Togni试剂通过丙烯酰胺的三氟甲基化丙烯酰胺的三氟甲基化来制备含CF ₃的恶唑啉，该方法在选择性生产所需的恶唑啉中起关键作用。用通常用于氧三氟甲基化的铜催化剂不能有效地进行反应。我们的方法提供了多种含CF ₃的恶唑啉，它们是药物，农用化学品和功能材料的潜在候选者。