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Enantioselective α-C-H functionalization of amides with indoles triggered by radical trifluoromethylation of alkenes: Highly selective formation of CCF3 and CC bonds
Journal of Fluorine Chemistry ( IF 1.9 ) Pub Date : 2017-03-19 , DOI: 10.1016/j.jfluchem.2017.03.008
Taotao Li , Peng Yu , Yi-Meng Du , Jin-Shun Lin , Yonggang Zhi , Xin-Yuan Liu

A dual copper/chiral phosphoric acid-catalyzed asymmetric tandem remote C(sp3)-H/unactivated alkene functionalization reaction triggered by radical trifluoromethylation of unactivated alkenes for the concomitant construction of CCF3 and CC bonds was described. This approach provided an efficient method for the synthesis of valuable chiral trifluoromethylated indole derivatives with excellent regio-, chemo-, and good enantioselectivity.



中文翻译:

由烯烃的自由基三氟甲基化引发的吲哚对酰胺的对映选择性α-CH功能化:C CF 3和C C键的高度选择性形成

描述了由未活化烯烃的自由基三氟甲基化引发的双铜/手性磷酸催化的不对称串联远程C(sp 3)-H /未活化烯烃官能化反应,用于CC CF 3CC键的伴随结构。这种方法为合成有价值的手性三氟甲基化的吲哚衍生物提供了一种有效的方法,该化合物具有出色的区域选择性,化学选择性和良好的对映选择性。

更新日期:2017-03-19
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