A set of triazole-based analogues of N-coumaroyltyramine was designed to discover potential leads that may help in the control of bacterial biofilms. the most potent compounds act as inhibitors of biofilm development with EC50 closed to ampicillin (EC50 = 11 μM) without toxic effect on bacterial growth even at high concentrations(100 μM).

中文翻译：

---

迈向无生物杀灭剂的智能生物膜策略：点击式合成肉桂酰胺类似物作为针对海洋细菌的抗生物膜化合物

设计了一组基于三唑的N-香豆素胺类似物，以发现可能有助于控制细菌生物膜的潜在线索。最有效的化合物可作为生物膜发展的抑制剂，EC50接近氨苄西林（EC50 = 11μM），即使在高浓度（100μM）下也对细菌生长没有毒性作用。