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To eat or not to eat — the metabolic flavor of ferroptosis
Current Opinion in Cell Biology ( IF 7.5 ) Pub Date : 2017-11-22 , DOI: 10.1016/j.ceb.2017.11.001
Minghui Gao , Xuejun Jiang

Ferroptosis is a newly defined iron-dependent, non-apoptotic mode of cell death with necrotic morphology. Distinctive from other death mechanisms, ferroptosis requires cellular iron and lipid peroxides, and is dictated by specific cellular metabolic processes. Importantly, ferroptosis has been implicated in a plethora of human diseases. This paper reviews the recent advances and outstanding questions of the field by focusing on the role of cellular metabolism in ferroptosis. The relevance of ferroptosis to disease and therapy is also discussed.



中文翻译:

吃还是不吃-肥大症的新陈代谢风味

Ferroptosis是一种新定义的铁依赖性,非凋亡的细胞死亡形态,具有坏死形态。与其他死亡机制不同的是,铁锈病需要细胞铁和脂质过氧化物,并受特定的细胞代谢过程的控制。重要的是,ferroptosis与许多人类疾病有关。本文着重研究细胞代谢在肥大症中的作用,回顾了该领域的最新进展和尚待解决的问题。还讨论了肥大症与疾病和治疗的关系。

更新日期:2017-11-22
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