The lip scarification model of herpes simplex virus type 1 (HSV-1) infection can be used to study acute infection in the orofacial tissue and the establishment of viral latency. In this study, mice were inoculated with HSV-1 and tissue harvested during the acute phase of infection. Clinical presentation of classical open sores on the lip of infected mice was observed. We defined the histopathology, disease scores, and immune infiltration of the lower lip during the formation and resolution of the clinical lesions. Finally, the kinetics of virus replication and transport of viral genomes to the trigeminal ganglia were established. With the virological and pathologic events of acute infection defined, the HSV-1 lip scarification model can now be used to study primary HSV-1 infection, invasion of the trigeminal ganglia, and establishment of latency.

单纯疱疹病毒1型（HSV-1）感染的唇裂模型可用于研究口面部组织的急性感染和病毒潜伏期的建立。在这项研究中，小鼠感染了HSV-1，并在感染的急性期收获了组织。观察到经典的开放性疮在感染小鼠嘴唇上的临床表现。我们定义了组织病理学，疾病评分以及在临床病变的形成和消退过程中下唇的免疫浸润。最后，建立了病毒复制和病毒基因组向三叉神经节运输的动力学。定义了急性感染的病毒学和病理学事件后，现在可以使用HSV-1唇裂模型来研究原发性HSV-1感染，三叉神经节的侵袭和潜伏期的建立。