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One-pot palladium-catalyzed synthesis of functionalized 10H-pyrido[1,2-a]quinoxalin-10-ones under copper-free conditions
Tetrahedron ( IF 2.1 ) Pub Date : 2017-11-22 , DOI: 10.1016/j.tet.2017.11.055 Atena Soozani , Ali Keivanloo , Mohammad Bakherad
中文翻译:
在无铜条件下一锅钯催化合成功能化的10 H-吡啶并[1,2- a ]喹喔啉-10-酮
更新日期:2017-11-22
Tetrahedron ( IF 2.1 ) Pub Date : 2017-11-22 , DOI: 10.1016/j.tet.2017.11.055 Atena Soozani , Ali Keivanloo , Mohammad Bakherad
Reactions of 3-substituted-2-chloroquinoxalines, terminal alkynes, and 1,3-dicarbonyl compounds in the presence of palladium catalyst afforded a number of 6,8,9-trisubstituted-10H-pyrido[1,2-a]quinoxalin-10-ones in 60–86% reaction yields. This one-pot protocol provided an efficient, practical, and direct method for the synthesis of pyrido[1,2-a]quinoxalines from readily available starting materials in the absence of a copper salt.
中文翻译:
在无铜条件下一锅钯催化合成功能化的10 H-吡啶并[1,2- a ]喹喔啉-10-酮
在钯催化剂存在下3-取代的2-氯喹喔啉,末端炔烃和1,3-二羰基化合物的反应得到许多6,8,9-三取代的10 H-吡啶并[1,2- a ]喹喔啉-10-ones的反应产率为60-86%。这种一锅法的方案提供了一种有效,实用,直接的方法,可以在没有铜盐的情况下,从容易获得的起始原料合成吡啶并[1,2- a ]喹喔啉。