A novel highly sensitive voltammetric quetiapine fumarate (QF) sensor based on a glassy carbon electrode (GCE) modified with carbon black nanoparticles (CB) was successfully developed. The electrochemical behaviour of the modified electrode and electrooxidation of quetiapine were investigated using cyclic voltammetry. The influence of the instrumental conditions and possible interfering substances was also examined. Under optimal conditions, the voltammetry calibration curve was linear in the quetiapine fumarate concentration range from 0.5 to 0.05 × 10⁻⁶ mol L⁻¹ with a detection limit of 7 × 10⁻⁹ mol L⁻¹ for a preconcentration time of 120 s. The reproducibility of the method measured as the relative standard deviation (RSD%) is 2.3% (n = 9) for 0.5 × 10⁻⁶ mol L⁻¹ of quetiapine. Moreover, the proposed method was successfully applied for quetiapine determination in pharmaceuticals as well as in human urine, and the obtained recovery was in the range from 99 to 107%.

中文翻译：

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炭黑纳米粒子修饰的玻碳电极在喹硫平高灵敏伏安法测定中的应用

基于碳黑纳米粒子（CB）修饰的玻碳电极（GCE）的新型高灵敏伏安喹硫平富马酸酯（QF）传感器已成功开发。使用循环伏安法研究了修饰电极的电化学行为和喹硫平的电氧化。还检查了仪器条件和可能的干扰物质的影响。在最佳条件下，富马酸喹硫平的浓度范围为0.5至0.05×10 ^-6 mol L ^-1时，伏安校准曲线是线性的，检出限为7×10 ^-9 mol L ^-1预浓缩时间为120 s。对于喹硫平的0.5×10 ^-6 mol L ^-1，以相对标准偏差（RSD％）衡量的方法的重现性为2.3％（n = 9）。此外，该方法成功地用于药物和人尿中喹硫平的测定，回收率在99％至107％之间。