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Palladium-catalyzed direct C–H ethoxycarbonylation of 2-aryl-1,2,3-triazoles and efficient synthesis of suvorexant
Organic Chemistry Frontiers ( IF 5.4 ) Pub Date : 2017-11-15 00:00:00 , DOI: 10.1039/c7qo00945c
Rui Sang 1, 2, 3, 4, 5 , Yang Zheng 1, 2, 3, 4, 5 , Hailong Zhang 1, 2, 3, 4, 5 , Xiaohua Wu 1, 2, 3, 4, 5 , Qiantao Wang 1, 2, 3, 4, 5 , Li Hai 1, 2, 3, 4, 5 , Yong Wu 1, 2, 3, 4, 5
Affiliation  

Efficient palladium-catalyzed C–H ethoxycarbonylation of 2-aryl-1,2,3-triazoles was developed by using diethyl azodicarboxylate as the esterification reagent. A wide variety of aryl esters containing 1,2,3-triazoles were obtained in moderate to good yields. In addition, density functional theory calculations were used to enhance the mechanistic studies.

中文翻译:

钯催化2-芳基-1,2,3-三唑的直接乙乙氧基羰基化反应及suvorexant的有效合成

使用偶氮二羧酸二乙酯作为酯化试剂,开发了钯催化的2-芳基-1,2,3-三唑的CHH乙氧基羰基化反应。以中等至良好的产率获得了多种包含1,2,3-三唑的芳基酯。另外,使用密度泛函理论计算来增强力学研究。
更新日期:2017-11-23
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