Titanium carbide MXene quantum dots (QDs) were synthesized using an effective fluorine-free method as a biocompatible and highly efficient nanoagent for photothermal therapy (PTT) applications. In contrast to the traditional, hazardous and time-consuming process of HF pretreatment, our fluorine-free method is safe and simple. More importantly, abundant Al oxoanions were found to be modified on the MXene QD surface by the fluorine-free method, which endowed the QDs with strong and broad absorption in the NIR region. As a result, the as-prepared MXene QDs exhibited an extinction coefficient as large as 52.8 Lg⁻¹ cm⁻¹ at 808 nm and a photothermal conversion efficiency as high as 52.2%. Both the values are among the best reported so far. The as-prepared MXene QDs achieved simultaneous photoacoustic (PA) imaging and the remarkable PTT effect of tumors. Moreover, MXene QDs showed great biocompatibility without causing noticeable toxicity in vitro and in vivo, indicating their high potential for clinical applications.

中文翻译：

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具有高近红外光热性能的碳化钛MXene量子点的无氟制备，用于癌症治疗

使用有效的无氟方法合成了碳化钛MXene量子点（QD），将其作为生物相容性和高效的纳米剂，用于光热疗法（PTT）应用。与传统的危险，费时的HF预处理方法相比，我们的无氟方法安全，简单。更重要的是，通过无氟方法在MXene QD表面改性了丰富的Al氧阴离子，这使QD在NIR区域具有强大而广泛的吸收能力。结果，所制备的MXene QD显示出高达52.8 Lg ^-1 cm ^-1的消光系数。在808nm处的光热转换效率高达52.2％。这两个值都是迄今为止报告的最好的值之一。所制备的MXene QD可以同时进行光声（PA）成像和显着的肿瘤PTT效应。而且，MXene QDs具有很好的生物相容性，并且在体外和体内都不会引起明显的毒性，这表明它们具有很高的临床应用潜力。