No culture shock: Polyproline is introduced as a mimic of antifreeze proteins, with ice recrystallisation inhibition activity linked to its amphipathic helix. These polymers are shown to enhance the cryopreservation of cultured cell monolayers. Polyproline can be obtained by synthetic and biosynthetic methods, making it an appealing macromolecular cryopreservative for storing donor cells and tissue.

中文翻译：

---

Polyproline作为最小的抗冻蛋白模拟物，可增强细胞单层的冷冻保存

无培养冲击：聚脯氨酸作为抗冻蛋白的模拟物被引入，其冰的重结晶抑制活性与其两亲性螺旋有关。这些聚合物显示增强了培养的细胞单层的冷冻保存。聚脯氨酸可以通过合成和生物合成方法获得，使其成为用于储存供体细胞和组织的有吸引力的大分子冷冻保存剂。