Catalytic asymmetric C2-nucleophilic substitutions of C3-substituted indoles such as tryptophols and tryptamines with ortho-hydroxybenzyl alcohols have been established, leading to the generation of triaryl methane products in generally high yields and excellent enantioselectivities (up to 99% yield, 98% ee). This class of C2-nucleophilic substitutions has wide substrate scope, which is not only applicable to a wide range of ortho-hydroxybenzyl alcohols, but also amenable to various tryptophols, tryptamines and other C3-substituted indoles. In addition, the reaction could be scaled up with maintained yield and enantioselectivity.

中文翻译：

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用邻羟基苄醇催化C3取代的吲哚的不对称C2亲核取代

已经建立了C3取代的吲哚（如三苯酚和色胺）的催化不对称C2亲核取代反应，使用邻羟基苄醇，通常以高收率和优异的对映选择性（高达99％，98％ee）生成三芳基甲烷产物。 ）。这类C 2-亲核取代具有广泛的底物范围，其不仅适用于广泛的邻-羟基苄醇，而且适用于各种胰多酚，色胺和其他C 3取代的吲哚。另外，可以在保持产率和对映选择性的同时扩大反应规模。