A diversified synthesis of 3-aminosugar analogues of digitoxin and digoxin with potent anticancer activities was explored. The synthesis was based on a highly efficient gold-catalyzed glycosylation reaction with alkynylbenzoate 3-aminoglycosides as glycosyl donors. According to this strategy, a small library containing digitoxin and digoxin analogues with various 3-aminosugar scaffolds was successfully constructed.

中文翻译：

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金催化的洋地黄毒苷和地高辛的3-氨基糖类似物的多样化合成

探索了具有强抗癌活性的洋地黄毒苷和地高辛的3-氨基糖类似物的多样化合成。该合成基于高效的金催化的糖基化反应，其中炔基苯甲酸酯3-氨基糖苷为糖基供体。根据该策略，成功构建了一个小型图书馆，该图书馆包含洋地黄毒苷和地高辛类似物以及各种3-氨基糖支架。