Selenium nanoparticles (SeNPs) with strong green scattering light serving as light scattering nanoprobes for dark-field microscopy imaging are developed for the first time. The SeNPs show good stability, excellent biocompatibility, and high light-producing power, and can precisely and specifically target cancer cells with overexpressed nucleolin (NCL) after modification with aptamers, revealing that the SeNPs can act as a good light scattering nanoprobe for bioimaging and biolabeling.

中文翻译：

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适体修饰的硒纳米粒子用于核仁素的暗场显微镜成像

首次开发了具有强绿色散射光的硒纳米颗粒（SeNP），用作用于暗场显微镜成像的光散射纳米探针。SeNPs表现出良好的稳定性，出色的生物相容性和较高的发光能力，并且经过适体修饰后，​​可以精确特异性地靶向过度表达的核仁蛋白（NCL）的癌细胞，这表明SeNPs可以作为生物成像和生物成像的良好光散射纳米探针。生物标记。