Phosphine catalysed (5 + 1) annulation of ynone/cinnamates with primary amines,Chemical Communications

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Phosphine catalysed (5 + 1) annulation of ynone/cinnamates with primary amines
Chemical Communications ( IF 4.9 ) Pub Date : 2017-11-10 00:00:00 , DOI: 10.1039/c7cc08252e
Jhi Ametovski _{1,

2,

3,

4,

5} , Uttam Dutta _{1,

2,

3,

4,

5} , Laura Burchill _{1,

2,

3,

4,

5} , Debabrata Maiti _{6,

7,

8,

9} , David W. Lupton _{1,

2,

3,

4,

5} , Joel F. Hooper _{1,

2,

3,

4,

5}

Affiliation

The (5 + 1) annulation of ynone/cinnamates and related substrates with protected primary amines gives rise to isoquinolones, pyrrolidinones and pyrrolopiperazines in good to excellent yields under phosphine catalysis. The reaction is viable with chiral phosphines, although the selectivity is poor.

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