Polymeric nanoparticles (NPs) of different morphologies (spheres and worms) were synthesized using a visible light mediated polymerization-induced self-assembly (PISA) approach. Spherical and worm-like NPs were subsequently modified to generate diazeniumdiolate functionalized NPs. Interestingly, the NO release rate and the dispersal of biofilms were found to strongly depend on the NP morphology. NPs with a higher aspect ratio (worms) exhibited a slower NO release rate and greater biofilm dispersal after 1 h of incubation.

中文翻译：

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使用光PISA制备的一氧化氮负载纳米颗粒进行生物膜扩散：形​​态学的影响

使用可见光介导的聚合诱导自组装（PISA）方法合成了不同形态（球形和蠕虫）的聚合物纳米颗粒（NPs）。随后修饰球形和蠕虫状NP，以生成二氮杂二氮烯鎓官能化的NP。有趣的是，发现NO释放速率和生物膜的扩散强烈依赖于NP形态。孵育1小时后，长径比较高的NP（蠕虫）显示出较慢的NO释放速率和更大的生物膜扩散。