In order to obtain an optimal therapeutic effect with minimal systemic toxicity, a redox-responsive mesoporous silica nanoparticle (MSN)-based platform modified with protoporphyrin IX (PpIX)-multifunctional peptides was synthesized as an intelligent theranostic agent carrier. This redox-responsive nanoplatform could release the theranostic agent under a glutathione stimulus, produce fluorescence recovery for tumor-specific fluorescence imaging and provide tumor-enhanced photodynamic therapy.

中文翻译：

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基于氧化还原反应的介孔二氧化硅纳米平台，用于体外肿瘤特异性荧光成像和增强的光动力疗法†

为了以最小的全身毒性获得最佳治疗效果，合成了用原卟啉IX（PpIX）多功能肽修饰的基于氧化还原反应的介孔二氧化硅纳米颗粒（MSN）平台，作为智能化治疗剂载体。这种氧化还原反应的纳米平台可以在谷胱甘肽刺激下释放治疗药物，为肿瘤特异性荧光成像产生荧光恢复，并提供增强肿瘤的光动力疗法。