Researchers have developed a new software tool, called LOHHLA, which can pinpoint allele-specific HLA loss in tumors. When applied to a cohort of patients with non–small cell lung cancer, this genomic event was detected in 40% of cases, increasing in frequency as the disease spread to the brain.

中文翻译：

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HLA丢失促进了免疫逃逸

研究人员开发了一种名为LOHHLA的新软件工具，该工具可以查明肿瘤中等位基因特异性HLA的丢失。当应用于非小细胞肺癌患者队列时，这种基因组事件在40％的病例中被检测到，随着疾病扩散到大脑的频率增加。