Buckminsterfullerene (C₆₀), known for its strong radical scavenging properties, has been studied extensively for its biomedical applications. Its clinical use would be promoted by novel functionalization of C₆₀ with the aid of drug delivery carriers based on nanoparticle technologies. Cellulose nanocrystals (CNCs) have recently been exploited as a promising nanoplatform for drug delivery, owing to their intriguing attributes such as nanoscale dimensions, low toxicity, broad chemical-modifying capacity, and biocompatibility. Herein, cellulose nanocrystals carrying buckminsterfullerene (CNC-C₆₀) have been synthesized via amine functionalization of CNCs and subsequent grafting of C₆₀ onto the surface of amine-terminated CNCs. FTIR and XPS measurements confirmed the success of the synthesis, which was further evidently supported by TGA analysis. Given atomic compositions of samples by elemental analysis, we figured out a C₆₀ content of 0.17 mmol/g of CNC-C₆₀, equivalent to 34 C₆₀ molecules/1000 anhydroglucose units (AGU). Afterward, CNC-C₆₀ was evaluated for its antiradical effects on scavenging hydroxyl radicals in vitro. The ease of synthesis and significant radical scavenging activity make CNC-C₆₀ a promising novel antioxidant agent for biomedical use.

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携带Buckminsterfullerene的纤维素纳米晶体的低温合成及其自由基清除性能

Buckminsterfullerene（C ₆₀），以其强大的自由基清除性能而闻名，已对其生物医学应用进行了广泛的研究。借助基于纳米粒子技术的药物输送载体，对C ₆₀进行新颖的功能化将促进其临床应用。纤维素纳米晶体（CNC）由于其引人入胜的特性，例如纳米级尺寸，低毒性，广泛的化学修饰能力和生物相容性，最近已被开发为有前途的药物输送纳米平台。本文中，已经通过CNCs的胺官能化和随后的C ₆₀接枝合成了携带buckminsterfullerene（CNC-C ₆₀）的纤维素纳米晶体。在胺封端的CNCs的表面上。FTIR和XPS测量证实了合成的成功，TGA分析进一步证明了合成的成功。通过元素分析给出样品的原子组成，我们得出的C ₆₀含量为0.17 mmol / g CNC-C ₆₀，相当于34 C ₆₀分子/ 1000脱水葡萄糖单位（AGU）。之后，评估了CNC-C ₆₀在体外清除羟基自由基方面的抗自由基作用。易于合成和显着的自由基清除活性使CNC-C ₆₀成为有前途的新型生物医学抗氧化剂。