Tanshinones were used as starting material to synthesize a small library of nitrogen heterocyclic derivatives featured with oxazole, imidazole, and pyrazine ring between C-11/C-12 by simple methods. Except for salviamine A and isosalviamine A, 22 new derivatives were synthesized. Their structures were confirmed by spectroscopic analysis. Moreover, 11 derivatives exhibited moderate cytotoxic activities against five human cancer lines in vitro.

中文翻译：

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含氮丹参酮衍生物的设计，合成和细胞毒性

丹参酮用作起始原料，可通过简单方法合成C-11 / C-12之间以恶唑，咪唑和吡嗪环为特征的小氮杂环衍生物库。除了唾液胺A和异水杨胺A以外，还合成了22种新的衍生物。通过光谱分析证实了它们的结构。此外，有11种衍生物在体外对5种人类癌症系表现出中等的细胞毒活性。