Phages invade microbes, accomplish host lysis and are of vital importance in shaping the community structure of environmental microbiota. More importantly, most phages have very specific hosts; they are thus ideal tools to manipulate environmental microbiota at species-resolution. The main purpose of MVP (Microbe Versus Phage) is to provide a comprehensive catalog of phage–microbe interactions and assist users to select phage(s) that can target (and potentially to manipulate) specific microbes of interest. We first collected 50 782 viral sequences from various sources and clustered them into 33 097 unique viral clusters based on sequence similarity. We then identified 26 572 interactions between 18 608 viral clusters and 9245 prokaryotes (i.e. bacteria and archaea); we established these interactions based on 30 321 evidence entries that we collected from published datasets, public databases and re-analysis of genomic and metagenomic sequences. Based on these interactions, we calculated the host range for each of the phage clusters and accordingly grouped them into subgroups such as ‘species-’, ‘genus-’ and ‘family-’ specific phage clusters. MVP is equipped with a modern, responsive and intuitive interface, and is freely available at: http://mvp.medgenius.info.

中文翻译：

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MVP：微生物-噬菌体相互作用数据库

噬菌体侵入微生物，完成宿主裂解，对塑造环境微生物群落结构至关重要。更重要的是，大多数噬菌体具有非常特定的宿主。因此，它们是在物种分辨率下操作环境微生物的理想工具。的主要目的MVP（中号icrobe V ERSUS PHage）可提供噬菌体与微生物相互作用的全面目录，并帮助用户选择可靶向（并可能操纵）特定微生物的噬菌体。我们首先从各种来源收集了50 782个病毒序列，然后根据序列相似性将它们分为33 097个独特的病毒簇。然后，我们确定了18608个病毒簇和9245个原核生物（即细菌和古细菌）之间的26572相互作用；我们基于从公开的数据集，公共数据库以及对基因组和宏基因组序列的重新分析中收集的30321个证据条目建立了这些相互作用。基于这些相互作用，我们计算了每个噬菌体簇的宿主范围，并相应地将它们分为亚类，例如“种-”，“属-”和“家族-”特异性噬菌体簇。MVP配备了现代化，响应迅速且直观的界面，可从以下网址免费获得：http : //mvp.medgenius.info。