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Cortactin: Cell Functions of A Multifaceted Actin-Binding Protein
Trends in Cell Biology ( IF 19.0 ) Pub Date : 2017-11-20 , DOI: 10.1016/j.tcb.2017.10.009
Michael Schnoor , Theresia E. Stradal , Klemens Rottner

Cortactin fulfills many functions in various cell types. These functions have been considered to derive from its ability to activate the Actin-related protein 2/3 (Arp2/3) complex, and are regulated by post-translational modifications, including phosphorylation and acetylation. New evidence suggests that cortactin regulates cell migration by controlling the deposition of extracellular matrix proteins rather than lamellipodial Arp2/3 activation, and that cortactin also functions in GTPase signaling, vesicular trafficking, and actomyosin contractility. These recent new findings and concepts are relevant for physiological and pathological cell functions, but have not yet been put into mechanistic context. Here, we reconsider current thinking on cortactin functions in different cell types during health and disease, and discuss potential directions of future research in cortactin biology.



中文翻译:

Cortactin:多面肌动蛋白结合蛋白的细胞功能

Cortactin在各种细胞类型中都具有许多功能。这些功能被认为源自其激活肌动蛋白相关蛋白2/3(Arp2 / 3)复合物的能力,并受翻译后修饰(包括磷酸化和乙酰化)的调节。新证据表明,cortactin通过控制细胞外基质蛋白的沉积而不是lalamlipodial Arp2 / 3激活来调节细胞迁移,并且cortactin在GTPase信号传导,囊泡运输和肌动球蛋白收缩中也起作用。这些最近的新发现和概念与生理和病理细胞功能有关,但尚未纳入机械学背景。在这里,我们重新考虑当前对健康和疾病中不同细胞类型中皮质激素功能的看法,

更新日期:2017-11-20
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