Small-molecule inhibition of TLR8 through stabilization of its resting state

Small-molecule inhibition of TLR8 through stabilization of its resting state, Published online: 20 November 2017; doi:10.1038/nchembio.2518

High-throughput screening identified potent small-molecule inhibitors of the endosomal Toll-like receptor TLR8 that stabilize the preformed TLR8 dimer in its resting state by binding to a unique site on the inactive dimer interface.

中文翻译：

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通过稳定其静止状态来小分子抑制TLR8

通过稳定其静止状态来小分子抑制TLR8

通过稳定其静止状态对TLR8进行小分子抑制，在线发布：2017年11月20日; doi：10.1038 / nchembio.2518

高通量筛选确定了内体Toll样受体TLR8的有效小分子抑制剂，该抑制剂可通过与非活性二聚体界面上的唯一位点结合，将预形成的TLR8二聚体稳定在其静止状态。