A dual role for a polyketide synthase in dynemicin enediyne and anthraquinone biosynthesis

A dual role for a polyketide synthase in dynemicin enediyne and anthraquinone biosynthesis, Published online: 20 November 2017; doi:10.1038/nchem.2876

The anthraquinone and enediyne halves of the antitumor antibiotic dynemicin A were previously thought to be assembled by two separate polyketide synthases (PKS). Now, a single polyketide synthase has been proposed to be responsible for their production, and a working model for their biosynthesis from a common octaketide intermediate has been suggested.

中文翻译：

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聚酮化合物合酶在地尼米二烯二炔和蒽醌生物合成中的双重作用

聚酮化合物合酶在地尼米二烯二炔和蒽醌生物合成中的双重作用

聚酮化合物合酶在地尼米二烯二炔和蒽醌生物合成中的双重作用，在线发布：2017年11月20日；doi：10.1038 / nchem.2876

以前认为抗肿瘤抗生素迪尼米星A的蒽醌和烯二炔半部是由两个单独的聚酮化合物合酶（PKS）组装而成的。现在，已经提出了一种单一的聚酮化合物合酶来负责其生产，并且已经提出了一种从普通的肽中间体进行生物合成的工作模型。