Structure-based inhibitors of tau aggregation,Nature Chemistry

当前位置： X-MOL 学术 › Nat. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Structure-based inhibitors of tau aggregation
Nature Chemistry ( IF 21.8 ) Pub Date : 2017-11-20 , DOI: 10.1038/nchem.2889
P M Seidler _{1,

2} , D R Boyer _{1,

2} , J A Rodriguez _{1,

2} , M R Sawaya _{1,

2} , D Cascio _{1,

2} , K Murray _{1,

2} , T Gonen ₃ , D S Eisenberg _{1,

2}

Affiliation

Structure-based inhibitors of tau aggregation

Structure-based inhibitors of tau aggregation, Published online: 20 November 2017; doi:10.1038/nchem.2889

Tau aggregation is associated with Alzheimer's disease and dozens of related dementias. Now atomic structures of the aggregation-prone segment VQIINK in repeat 2 of tau have been reported. Inhibitors designed using these structures block seeding by full-length tau better than inhibitors that target the VQIVYK aggregation segment in repeat 3.

中文翻译：