Stimuli-responsive nanostructures have shown great promise for intracellular delivery of anticancer compounds. A critical challenge remains in the exploration of stimuli-responsive nanoparticles for fast cytoplasmic delivery. Herein, near-infrared (NIR) light-responsive nanoparticles were rationally designed to generate highly efficient cytoplasmic delivery of anticancer agents for synergistic thermo-chemotherapy. The drug-loaded polymeric nanoparticles of selenium-inserted copolymer (I/D-Se-NPs) were rapidly dissociated in several minutes through reactive oxygen species (ROS)-mediated selenium oxidation upon NIR light exposure, and this irreversible dissociation of I/D-Se-NPs upon such a short irradiation promoted continuous drug release. Moreover, I/D-Se-NPs facilitated cytoplasmic drug translocation through ROS-triggered lysosomal disruption and thus resulted in highly preferable distribution to the nucleus even in 5 min postirradiation, which was further integrated with light-triggered hyperthermia for achieving synergistic tumor ablation without tumor regrowth.

中文翻译：

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光响应纳米粒子高效抗癌剂的细胞质传递。

刺激响应的纳米结构已显示出在细胞内递送抗癌化合物的巨大希望。在探索刺激应答性纳米颗粒以快速细胞质递送方面仍然存在关键挑战。本文中，近红外（NIR）光响应纳米粒子经过合理设计，可产生高效的细胞质递送抗癌剂，用于协同热化学疗法。掺硒共聚物（I / D-Se-NPs）的载药聚合物纳米粒子在近红外照射下通过活性氧（ROS）介导的硒氧化在几分钟内迅速解离，并且I / D的这种不可逆解离如此短的照射后，Se-NPs促进了药物的连续释放。而且，