Direct α-alkylation of amides and the synthesis of C3-alkylated 3-hydroxyindolin-2-one/2-substituted-2-hydroxy-3,4-dihydronaphthalen-1(2H)-one derivatives from 2-oxindole/1-teralone were reported using primary alcohols in the presence of Ru-NHC catalyst in a one pot condition under the borrowing hydrogen method. In the case of inert conditions, 2-oxindole/1-teralone exclusively forms the C3-alkylated product. Whereas, allowing this reaction mixture to occur under an air atmosphere predominantly forms C3-alkylated 3-hydroxyindolin-2-one via domino C–H alkylation and aerobic C–H hydroxylation. This Ru-NHC catalyst is easily accessible, air stable, and phosphine free. Using this method, synthesis of 2-oxindole based natural products such as Donaxaridine was accomplished.

中文翻译：

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Ru-NHC催化的羰基化合物与醇的多米诺反应：Donaxaridine的短合成

酰胺的直接α-烷基化反应和由2-oxindole / 1-合成C3-烷基化的3-hydroxyindolin-2-one / 2-取代的-2-hydroxy-3,4-dihydronaphthalen-1（2 H）-one衍生物据报道，在Ru-NHC催化剂存在下，在借用氢气法的一锅条件下，使用伯醇使用了三氢萘酮。在惰性条件下，2-oxindole / 1-teralone专门形成C3-烷基化产物。而使这种反应混合物在空气气氛下发生，主要是通过多米诺骨牌C–H烷基化和有氧C–H羟基化形成C3-烷基化的3-羟基吲哚-2-酮。这种Ru-NHC催化剂易于获取，空气稳定且不含膦。使用该方法，完成了基于2-氧吲哚的天然产物例如多那西啶的合成。