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Stable, polyvalent aptamer-conjugated near-infrared fluorescent nanocomposite for high-performance cancer cell-targeted imaging and therapy
Journal of Materials Chemistry B ( IF 7 ) Pub Date : 2017-11-07 00:00:00 , DOI: 10.1039/c7tb02218b
Yan-Jun Zhu 1, 2, 3, 4, 5 , Wen-Jing Li 1, 2, 3, 4, 6 , Zhang-Yong Hong 1, 2, 3, 4, 6 , An-Na Tang 1, 2, 3, 4, 5 , De-Ming Kong 1, 2, 3, 4, 5
Affiliation  

Early diagnosis and targeted therapy are two important ways to improve cancer treatment survival. In this work, via a simple DNA hybridization reaction, DNA-templated fluorescent silver nanoclusters (AgNCs) were successfully assembled around a DNA-modified gold nanoparticle (AuNP) to construct a novel nanocomposite with the functions of cancer cell-specific imaging and targeted therapy. The as-prepared AuNP@(AS1411–AgNCs)n nanocomposite shows strong near-infrared fluorescence emission and improved biostability, and carries a high density of AS1411—the first anticancer aptamer targeting nucleolin protein, which is over-expressed not only on the surface but also in the cytoplasm of cancer cells. The synergy of multivalent AS1411–nucleolin binding promotes accumulation of the nanocomposite towards cancer cells and subsequent internalization in them. This results in highly specific cancer cell-targeted imaging and selective killing in a low AuNP@(AS1411–AgNCs)n concentration range. The prepared nanocomposite also shows great potential as a carrier of doxorubicin to further promote the selective killing of cancer cells.

中文翻译:

稳定的,多价适体偶联的近红外荧光纳米复合材料,用于高性能靶向癌细胞的成像和治疗

早期诊断和靶向治疗是提高癌症治疗生存率的两种重要方法。在这项工作中,通过简单的DNA杂交反应,成功地围绕DNA修饰的金纳米颗粒(AuNP)组装了以DNA为模板的荧光银纳米簇(AgNC),以构建具有癌细胞特异性成像和靶向治疗功能的新型纳米复合材料。 。准备好的AuNP @(AS1411–AgNCs)n纳米复合材料显示出强大的近红外荧光发射和改善的生物稳定性,并具有高密度的AS1411 —第一种靶向核仁蛋白的抗癌适体,不仅在表面而且在癌细胞的细胞质中都过表达。多价AS1411-核仁素结合的协同作用促进了纳米复合材料向癌细胞的积累和随后的内在化。这导致在低AuNP @(AS1411–AgNCs)n浓度范围内高度特异性靶向癌细胞的成像和选择性杀伤。制备的纳米复合材料还具有作为阿霉素载体的巨大潜力,可以进一步促进癌细胞的选择性杀伤。
更新日期:2017-11-21
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