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Pharmacology of predatory and defensive venom peptides in cone snails
Molecular BioSystems Pub Date : 2017-11-01 00:00:00 , DOI: 10.1039/c7mb00511c
Jutty Rajan Prashanth 1, 2, 3, 4, 5 , Sebastien Dutertre 6, 7, 8, 9, 10 , Richard James Lewis 1, 2, 3, 4, 5
Affiliation  

Cone snails are predatory gastropods whose neurotoxic venom peptides (conotoxins) have been extensively studied for pharmacological probes, venom evolution mechanisms and potential therapeutics. Conotoxins have a wide range of structural and functional classes that continue to undergo accelerated evolution that underlies the rapid expansion of the genus over their short evolutionary history. A number of pharmacological classes, driven by separately evolved defensive and predatory venoms, have been hypothesised to facilitate shifts in prey that exemplify the adaptability of cone snails. Here we provide an overview of these pharmacological families and discuss their ecological roles and evolutionary impact.

中文翻译:

锥蜗牛中掠食性和防御性毒液肽的药理作用

锥蜗牛是掠食性腹足动物,其神经毒性毒液肽(毒素)已被广泛研究用于药理探针,毒液进化机制和潜在的治疗方法。芋螺毒素具有广泛的结构和功能类别,它们继续经历加速的进化过程,这是该属在其短暂的进化历史中迅速扩展的基础。已提出了由分别演化的防御性和掠食性毒液驱动的许多药理学类别,以促进猎物的移动,从而证明了锥蜗牛的适应性。在这里,我们提供了这些药理家族的概述,并讨论了它们的生态作用和进化影响。
更新日期:2017-11-21
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