As they differentiate, thymocytes encounter spatially restricted cues critical for differentiation and selection of a functional, self-tolerant T cell repertoire. Sequential migration of developing T cells through distinct thymic microenvironments is enforced by the ordered expression of chemokine receptors. Herein, we provide an updated perspective on T cell differentiation through the lens of recent advances that illuminate the dynamics of chemokine-driven thymocyte migration, localization, and interactions with stromal cells. We consider these findings in the context of earlier groundwork exploring the contribution of chemokines to T cell development, recent advances regarding the specificity of chemokine signaling, and novel techniques for evaluating the T cell repertoire. We suggest future research should amalgamate visualization of localized cellular interactions with downstream molecular signals.

中文翻译：

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趋化因子介导的胸腺细胞发育和选择编排。

在分化过程中，胸腺细胞会遇到空间受限的信号，这些信号对于分化和选择功能性，自耐受性T细胞库至关重要。趋化性T细胞通过不同的胸腺微环境的顺序迁移是通过趋化因子受体的有序表达来实现的。本文中，我们通过最近的进展提供了有关T细胞分化的最新观点，阐明了趋化因子驱动的胸腺细胞迁移，定位以及与基质细胞相互作用的动力学。我们在探索趋化因子对T细胞发育的贡献的早期基础工作，趋化因子信号传导特异性的最新进展以及评估T细胞库的新技术的早期基础研究中考虑了这些发现。