当前位置: X-MOL 学术Carbohydr. Polym. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Synthesis of carbohydrate conjugated 6A,6D-bifunctionalized β cyclodextrin derivatives as potential liver cancer drug carriers
Carbohydrate Polymers ( IF 11.2 ) Pub Date : 2017-11-20 , DOI: 10.1016/j.carbpol.2017.11.054
Yili Ding , Chamakura V.N.S. Vara Prasad , Charles Ding , Bingyun Wang

Galactosyl and lactosyl conjugated 6A,6D-bifunctionlized β cyclodextrin derivatives were designed and synthesized as the potential liver cancer drug carriers through SN2 replacement and click reactions in order to increase liver cancer drug’s targeting ability, solubility and stability. The synthetic methods and strategies to obtain the designed compounds were discussed.



中文翻译:

碳水化合物共轭6A,6D-双功能β-环糊精衍生物的合成作为潜在的肝癌药物载体

通过SN2置换和点击反应设计并合成了半乳糖和乳糖基共轭的6A,6D双功能β环糊精衍生物,作为潜在的肝癌药物载体,以提高肝癌药物的靶向能力,溶解性和稳定性。讨论了获得设计化合物的合成方法和策略。

更新日期:2017-12-06
down
wechat
bug