Topical absorbable hemostats are routinely utilized in surgical procedures to assist in controlling intraoperative bleeding. SURGICEL Original Absorbable Hemostat, one of the most frequently used adjunctive hemostats, is composed of oxidized regenerated cellulose (ORC). We report here that a novel powdered form of ORC, composed of aggregates of ORC fine fibers, provides additional valuable hemostatic performance characteristics and retains the biochemical and bactericidal profile of the parent ORC fabric. The ORC aggregates are more effective in promoting coagulation than their constituent ORC fine fibers because of more favorable surface energetics and surface area. Aggregates with similar particle size distributions that have higher sphericity values exhibit better coagulation efficacy. Finally, ORC aggregates more effectively promote clot formation than starch-based hemostatic particles. The results of this investigation indicate that the efficacy of this novel powdered hemostat is based on its chemical composition, morphology, and particle surface energetics.

中文翻译：

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可吸收止血骨料

局部可吸收止血剂通常用于外科手术中，以帮助控制术中出血。SURGICEL Original Absorbable Hemostat是最常用的辅助止血剂之一，由氧化再生纤维素（ORC）组成。我们在这里报告说，由ORC细纤维的聚集体组成的ORC的新型粉末形式，提供了其他宝贵的止血性能特征，并保留了母体ORC织物的生化和杀菌特性。ORC聚集体比其组成的ORC细纤维更有效地促进凝聚，因为它具有更有利的表面能和表面积。具有较高球形度值的相似粒度分布的聚集体表现出更好的凝结功效。最后，ORC聚集体比淀粉基止血颗粒更有效地促进血凝块形成。这项研究的结果表明，这种新型粉末止血药的功效是基于其化学成分，形态和颗粒表面能。