Effective and safe doses of opiate painkillers, like morphine, can be limited by respiratory depression. Schmid et al. (2017) now present a quantitative method to design ligands and correlate GPCR signaling bias to the dose separation between therapeutic and adverse effects in animals.

中文翻译：

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调整偏置GPCR信号以获取生理增益。

阿片类镇痛药（如吗啡）的有效和安全剂量可能会因呼吸抑制而受到限制。Schmid等。（2017）现在提出了一种定量方法来设计配体，并将GPCR信号偏向与动物治疗和不良反应之间的剂量分离相关联。