In this work a novel and simple electrochemical sensor for the determination of (S)-warfarin based on an activated screen printed gold/Au nanoparticles/molecularly imprinted polymer electrode (ASPG/AuNPs/MIP) was introduced. Cyclic voltammetry, differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy were used to investigate the electrochemical behavior of (S)-warfarin at the modified electrode under optimum conditions. According to the results, ASPG/AuNPs/MIP showed a linear range for (S)-warfarin concentrations from 5.0 nM to 1.0 μM and a limit of detection of 1.0 nM by DPV. The proposed sensor was used for the determination of (S)-warfarin in commercial tablets, human serum and urine with satisfactory results.

中文翻译：

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使用金纳米颗粒和对映选择性分子印迹聚合物修饰的活化丝网印刷金电极测定（S）-华法林

在这项工作中，介绍了一种基于活化的丝网印刷金/金纳米颗粒/分子印迹聚合物电极（ASPG / AuNPs / MIP）的新颖，简单的电化学传感器，用于测定（S）-华法林。循环伏安法，差分脉冲伏安法（DPV）和电化学阻抗谱用于研究（S）-华法林在最佳条件下在修饰电极上的电化学行为。根据结果​​，ASPG / AuNPs / MIP对（S）-华法林浓度的线性范围为5.0 nM至1.0μM，而DPV的检测极限为1.0 nM。建议的传感器用于确定（S-华法林在市售片剂，人血清和尿液中均具有令人满意的结果。