Transition metal-catalysed C–H bond functionalisation is an attractive approach for assembling valuable complex intermediates for the synthesis of pharmaceuticals, natural products, agrochemicals and fine chemicals. Selective functionalisation of one specific C–H site within a complex molecule without the assistance of a directing group is one of the major challenges in organic synthesis. The non-directed functionalisation of C–H bonds is more attractive and straightforward than the directed approach. While several reviews have covered (hetero)aryl (pseudo)halides as coupling partners in non-directed C–H bond functionalisation, this review will complement these existing contributions by focusing on the recent developments involving the employment of organometallic reagents for palladium-catalysed non-directed C–H bond functionalisation of (hetero)arene C–H bonds. Additionally, C–H/C–H bond coupling and other coupling partners will also be fully described.

中文翻译：

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钯催化的（杂）芳基合成中（杂）芳烃C–H键与C–Z（Z = B，Si，Sn，S，N，C，H）键的钯催化非定向偶联的最新进展

过渡金属催化的C–H键功能化是一种有吸引力的方法，可用于组装有价值的复杂中间体，用于合成药物，天然产物，农用化学品和精细化学品。在有机分子中，一个复杂的分子中一个特定的C–H位点的选择性功能化，而没有一个导向基团的帮助，是一个主要的挑战。碳氢键的非定向功能比定向方法更具吸引力和直接性。尽管有几篇评论文章涵盖了（杂）芳基（假）卤化物作为非定向CH键功能化过程中的偶联伙伴，这篇综述将通过关注有机金属试剂在钯催化的（杂）芳烃CH键的非定向CH键功能化方面的最新进展，对现有的研究做出补充。此外，还将全面描述C–H / C–H键耦合和其他耦合伙伴。